University of Queensland researchers say the discovery of a new stress reduction role for a naturally occurring molecule in the body could lead to new drugs and treatment for metabolic disorders and ageing.

Professor Steven Zuryn, a molecular geneticist from UQ’s Queensland Brain Institute, was part of a team that found very small RNA molecules, called microRNAs, bind to genes and prevent them from being over-activated.

The study specifically investigated damage to mitochondria the parts of cells that supply energy to enable muscles to work, neurons to fire and almost every other process occurring in the body.

“Damage to the mitochondria accrues over time and is closely associated with metabolic disorders and diseases of ageing including neurodegeneration, cancer and diabetes, as well as ageing itself,’’ Professor Zuryn said.

“There are also Mitochondrial diseases which are devastating, are passed down through the mother's side, and which can manifest in young children or adults.“Essentially, these microRNAs lower chronic stress in the body and protect cells by controlling mitochondrial stress signals.’’

This study looked at a specific microRNA, called miR-71.

“Our research implies that we could design highly specific and deliverable microRNAs that target these same genes in humans, thereby reducing the intensity and spread of damaging chronic stress signals,’’ Professor Zuryn said. 

Source: https://news.uq.edu.au/2026-01-new-potential-treating-ageing-and-metabolic-disorders