Aging & Gerontology

Diagnostic uncertainty in Parkinson's disease: New study calls for improved diagnostic processes

Study finds 17.7% of Parkinson’s diagnoses revised over 10 years, highlighting challenges in accurate, long-term diagnosis.Readmore

UCalgary researchers find important clues contributing to Alzheimer's disease

How the brain interacts with the vascular system may be key to reducing disease riskReadmore

Pioneering tests could improve the assessment of dementia in ageing Africans

International researchers have introduced two improved tests that could precisely detect cognitive dysfunction in older African adults.Readmore

AI effectively predicts dementia risk in American Indian/Alaska Native elders

UC Irvine study provides framework for how machine learning models identify novel predictorsReadmore

Older adults experience similar or even less muscle damage than young adults after exercise

Older adults experience less muscle soreness after exercise, challenging the belief that aging muscles recover more slowly.Readmore

Study strengthens link between shingles vaccine and lower dementia risk

A study in Wales suggests the shingles vaccine may reduce dementia risk by 20%, offering new hope for prevention.Readmore

Mass General Brigham Researchers Reveal 17 Modifiable Risk Factors Shared by Stroke, Dementia, and Late-Life Depression

Modifying shared lifestyle risk factors can reduce the risk of stroke, dementia, and late-life depression, according to a Mass General Brigham study.Readmore

Key differences between visual- and memory-led Alzheimer’s discovered

Differences in the distribution of certain proteins and markers in the brain may explain why some people first experience vision changes instead of memory loss in Alzheimer’s disease, finds a new study by UCL researchers.Readmore

How GPS helps older drivers stay on the roads

GPS navigation helps older adults maintain driving independence by reducing spatial challenges, according to new research.Readmore

Many older adults send their doctors portal messages, but who pays?

People covered by Medicaid are just as likely as those with private insurance to face a co-pay or other charge for sending a message to their physician or other providerReadmore

Exercise as an anti-ageing intervention to avoid detrimental impact of mental fatigue

Retired adults who habitually exercised outperformed sedentary adults in physical and cognitive tests.Readmore

Five myths about gerontology dispelled by a University of Idaho professor

Gerontology goes beyond healthcare it's a dynamic, multidisciplinary field shaping how we live, age, and thrive across all stages of life.Readmore

Linking blood flow and brain health

ME researchers are using imaging methods to learn how blood flow may impact the hippocampus.Readmore

Highly accurate blood test diagnoses Alzheimer’s disease, measures extent of dementia

A new blood test for Alzheimer’s can diagnose the disease and determine its stage, aiding in personalized treatment decisions.Readmore

Students lead breakthrough study on diabetes drugs and dementia risk

Undergraduate students at University of Galway led a major study linking GLP-1 receptor agonists to reduced dementia risk in diabetes patients.Readmore

ALS drug effectively treats Alzheimer’s disease in new animal study

NU-9 acts on a common mechanism at play in both neurodegenerative diseasesReadmore

Mizzou researchers discover natural compound may slow ALS and dementia

A new study from the University of Missouri shows a compound found in certain fruits and vegetables could hold key to treating neurodegenerative diseases.Readmore

Eye health linked to dementia risk

A University of Otago study found that retinal blood vessel changes may signal early dementia risk, offering potential for future eye-scan-based screening.Readmore

More opportunities to test for Alzheimer’s using new analytical method

A new simplified blood test for Alzheimer’s shows over 90% accuracy, making early diagnosis more accessible worldwide.Readmore

Potential Alzheimer’s Disease Therapeutic Target Identified in Brain Immune Cells

Researchers identified Tim-3 as a key microglial regulator and potential Alzheimer’s therapy target, enhancing plaque clearance and reducing neuroinflammation.Readmore

New Study Explores the Need for Expanded Long-Term Care Services to Support Aging-in-Place

A recent Johns Hopkins study underscores the urgent need to strengthen long-term care services to support aging-in-place for the growing U.S. elderly population.Readmore

Social isolation linked to poor diet in older women

A UBC study finds persistently isolated older Canadian women have poorer diet quality due to reduced fruit and vegetable intake, highlighting the impact of long-term social connection on healthy eating.Readmore

Alternative to hip replacement keeps aging athletes in the game

Birmingham hip resurfacing enables active adults to stay highly active for over a decade with fewer complications than total hip replacement, a Washington University study finds.Readmore

AI tool unlocks long-standing biomedical mystery behind Alzheimer’s, Parkinson’s

RibbonFold, a novel AI tool, accurately predicts misfolded amyloid protein structures, advancing understanding and treatment of neurodegenerative diseases like Alzheimer’s and Parkinson’s.Readmore

Alzheimer's research at SRH University: How ibuprofen affects fat metabolism in the brain

A new study reveals ibuprofen has both protective and harmful effects on brain lipid metabolism, offering insights into its complex role in Alzheimer's prevention and therapy.Readmore

Digital technology and AI can support workers with dementia – new research

New research highlights how digital technology can help people with dementia maintain productive working lives.Readmore

ITSN1 gene linked to risk of Parkinson’s disease

A new study identifies ITSN1 genetic variants as a major risk factor for Parkinson’s disease, paving the way for potential therapeutic advancements.Readmore

HKU study shows bad sleep harms old-age memory by disrupting the brain’s ‘waste removal system’

Poor sleep in older adults disrupts the brain’s glymphatic system, affecting memory and cognitive health.Readmore

Compound found in common herbs inspires potential anti-inflammatory drug for Alzheimer’s disease

Scripps Research scientists created a stable form of carnosic acid, observing greater memory function and other disease improvements in mice.Readmore

UMass Chan-led study finds regularly updating cognitive data improves ability to predict Alzheimer’s disease

Researchers developed a dynamic prediction model for Alzheimer's disease that continuously updates cognitive risk factors to improve early detection and intervention.Readmore

Vocal changes in birds may predict age-related disorders in people, study finds

University of Arizona neuroscientists found that aging alters gene expression in songbirds' brains, affecting vocal production—insights that may aid early diagnosis and treatment of neurodegenerative diseases like Parkinson’s and Alzheimer’s.Readmore

UWF studies positive impacts of dance for individuals with dementia

A study by a team of University of West Florida researchers, conducted with Council on Aging of West Florida’s adult day care, The Retreat, uncovered insights into the positive impact of dance on individuals living with Alzheimer’s and related dementias.Readmore

Earlier menopause and poor synaptic health could raise Alzheimer's risk: Study

These findings highlight the importance of both hormonal factors and synaptic health in influencing [Alzheimer’s disease] risk in womenReadmore

Anti-amyloid drug shows signs of preventing Alzheimer’s dementia

Clinical trial of people destined to develop early-onset Alzheimer’s disease shows eliminating amyloid from brain may prevent symptoms, supports need for confirmatory studiesReadmore

Dementia patients and their carers to be asked about direction of drug research

Cambridge researchers seek input from dementia patients and families on repurposing existing drugs for clinical trials to slow or halt disease progression.Readmore

More young people are caring for a loved one with dementia. It takes a unique toll

Caring for a loved one with dementia, particularly if they’re a parent, takes a unique emotional toll on a young person. They need better support.Readmore

Elderly neurological patients are open to in-home remote monitoring

Elderly neurological patients are open to home-based remote monitoring, with caregiver support enhancing acceptance.Readmore

Weather emergencies affect older adults' health views

People over 50 who recently experienced an extreme weather event far more likely to express concern about the effects of climate change on their healthReadmore

Understanding older care leavers’ perceptions and experiences of aged care services

A new review led by the National Centre for Healthy Ageing and Monash University highlights the challenges faced by older care leavers in aged care, emphasizing the need for trauma-informed, person-centered support.Readmore

Mass General Brigham Researchers Develop and Study an At-Home Smell Test for Early Detection of Alzheimer’s Disease

A new study suggests that olfactory testing may help detect early cognitive impairment, potentially aiding in the early diagnosis of neurodegenerative diseases like Alzheimer's.Readmore

Healthy eating in midlife linked to overall healthy aging

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Is Increased Sleepiness in Our 80s Tied to Higher Dementia Risk?

Changing sleep patterns in older adults, especially increasing sleepiness, may double the risk of dementia, according to a Neurology study.Readmore

Pennington Biomedical Researchers Identify Neurons in Brain that Regulate Energy Levels and Body Temperature

Research shows that the brain area that helps control body temperature, energy use and eating habits uses specific chemical and neuronic pathways to influence regulating adjustments. Readmore

How Your Brain Manages Cholesterol Could Increase Alzheimer’s Risk

In breakthrough, UCSF study shows that cholesterol-hungry parts of the brain are more vulnerable to Alzheimer’s amyloid-beta plaques, suggesting potential treatment targets.Readmore

Memory is impaired in aged rats after 3 days of high-fat eating

Study finds diet-related brain inflammation without metabolic changesReadmore

Alzheimer’s disease, dementias chronically undiagnosed yet early detection rarely used

A University of Michigan study finds cognitive screening for Alzheimer’s remains underused despite its benefits. Researchers emphasize the need for greater awareness and access to early diagnosis and treatment.Readmore

AI may aid in the timely diagnosis of schizophrenia and bipolar disorder

Schizophrenia and bipolar disorder are severe mental illnesses that emerge in early adulthood, requiring precise diagnosis for effective treatment, though diagnosis can be complex.Readmore

Mount Sinai-Led Research Team Identifies Underlying Mechanisms of Age-Related Dysfunction in Glands Crucial to Eye Function

Mount Sinai researchers identified stem cell mechanisms behind age-related meibomian gland degeneration, paving the way for new treatments for evaporative dry eye disease.Readmore

Herpesviruses may contribute to Alzheimer’s disease via transposable elements

HSV-1 is associated with Alzheimer’s-associated transposable elements in infected, Alzheimer’s-affected brains, which may be reversed through available drugs.Readmore

Immune cells may lead to more Parkinson’s cases in men

LJI scientists uncover autoimmune response that may help explain why Parkinson's disease is twice as common in male patientsReadmore

Rice researchers unravel menopause timing, shedding light on ovarian aging and fertility

A new study from Rice University uses stochastic analysis to model ovarian aging, predicting menopause timing with greater accuracy. The findings reveal how follicular transitions influence variability and population-wide trends in menopause.Readmore

New AI Model Measures How Fast the Brain Ages

The first-of-its-kind tool can non-invasively track the pace of brain changes using MRI scans; faster brain aging closely correlates with a higher risk of cognitive impairment.Readmore

Study: Extreme Heat May Speed Up Aging in Older Adults

People in neighborhoods that experience more days of high heat show faster aging at the molecular level than residents of cooler regions, say USC researchers.Readmore

Digital Program Reduces Fall Risk and Boosts Strength in Older Adults

Study highlights the success of an online exercise program tailored for seniorsReadmore

Loyal Receives FDA Acceptance of Reasonable Expectation of Effectiveness for Senior Dog Lifespan Extension

Loyal, a clinical-stage animal health company, has secured FDA acceptance for LOY-002’s effectiveness in extending senior dogs' lifespan and raised $22M in funding to advance its longevity drug portfolio.Readmore

Key protein identified for understanding and treating Alzheimer’s disease

Researchers at the University of Cologne have identified a specific form of the tau protein that is responsible for mediating the toxicity of harmful protein clumps in human neurons and thus represents a new target for future treatmentsReadmore

Shared Pathways in HIV and Aging May Contribute to Heart Failure Risk

Scientists have identified a unique protein signature in the blood of people living with HIV, linked to aging and increased heart failure risk. This discovery may help refine risk prediction models and uncover new therapeutic targets for heart failure.Readmore

Among Older Women, Hormone Therapy Linked to Tau Accumulation, a Hallmark of Alzheimer’s Disease

Menopausal hormone therapy (HT) linked to faster tau accumulation in women over 70, potentially increasing Alzheimer’s risk. Timing of HT initiation is crucial.Readmore

The ‘Silent’ X Chromosome Gives the Aging Female Brain a Boost

In a surprise, work in mice has found that the dormant X chromosome in females can reawaken late in life and turn on genes that keep the brain healthy.Readmore

Scientists Identify Critical “Midlife Window” for Preventing Age-Related Brain Decline

Groundbreaking research reveals metabolic interventions could help prevent cognitive agingReadmore

Brain mapping unlocks key Alzheimer’s insights

A UTA, University of California–San Francisco study explores why some nerve cells are more vulnerable to neurodegenerationReadmore

New Frailty Measurement Tool Could Help Identify Vulnerable Older Adults in Epic

Mass General Brigham researchers developed an AI-driven tool that identifies frailty in older adults using electronic health records, helping predict emergency care needs, rehospitalization, and mortality risk.Readmore

His genes forecast Alzheimer's. His brain had other plans.

Doug Whitney, 75, carries a rare Alzheimer’s-causing gene mutation but remains symptom-free, possibly due to high levels of heat shock proteins. Scientists are studying his case to uncover new protective strategies against the disease.Readmore

1 in 5 older adults get infections after heart surgery, and women have a 60% higher risk

Investigators say postoperative infections may be greatly underestimatedReadmore

AI-driven robotics research aims to enhance care for older adults with Alzheimer’s

AI-powered robot Ruyi is being studied at Case Western Reserve University to enhance senior care and support individuals with early-stage Alzheimer's.Readmore

Throat microbiome holds clues to older Australians’ health

Flinders University researchers have identified Staphylococcus aureus as a potential microbial marker for assessing health risks in aged care residents.Readmore

Blood test shows promise for early detection of dementia

Research findings focus on people with a sleep disorder, but could have broader implicationsReadmore

Treatment for Alzheimer’s may lie in the brain’s own cleanup crew

Brain’s immune cells cleared plaques, restored a healthier brain environment in immunized patient brainsReadmore

Understanding How Metabolism Contributes to Parkinson’s Disease

Northwestern Medicine researchers discovered that mitochondrial dysfunction in Parkinson’s disease disrupts metabolism, leading to neuronal damage. Targeting alpha-ketoglutarate dehydrogenase may offer new therapeutic possibilities.Readmore

One-third of older Canadians at nutritional risk, study finds

A University of Waterloo study found that one-third of Canadian adults aged 55+ are nutritionally at risk, increasing healthcare use, highlighting the need for routine nutrition screening like SCREEN-8.Readmore

Prenuvo Announces it Had Raised $120M to Advance Preventative Health, Launches Novel FDA-Cleared AI-Powered Products

Prenuvo, a leader in proactive whole-body MRI screening, raised $120M in Series B funding and secured FDA clearance for its AI-powered body composition report, reinforcing its role in preventative healthcare innovation.Readmore

‘Healthy’ Vitamin B12 Levels Not Enough to Ward Off Neuro Decline

UCSF-led study calls for new recommendations and supplements for older adults that may offer better brain protection.Readmore

Older people in England report greater life satisfaction than before the Covid pandemic

Older people have greater life satisfaction and sense of life’s worth than they did before the Covid-19 pandemic, finds a new study led by a UCL researcher.Readmore

Neko Health raises $260m Series B

Preventative healthcare tech company Neko Health, co-founded by Hjalmar Nilsonne and Daniel Ek, has secured $260M in Series B funding.Readmore

Vertex Announces FDA Approval of JOURNAVX™ (suzetrigine), a First-in-Class Treatment for Adults With Moderate-to-Severe Acute Pain

Vertex Pharmaceuticals has received FDA approval for JOURNAVX™ (suzetrigine), a first-in-class treatment for moderate-to-severe acute pain in adults. This marks a major advancement in non-opioid pain management, offering a new option for patients in need.Readmore

Innovative theatre project bringing laughter to people living with dementia

A pioneering new theatre project, created with help from Swansea University, has been bringing joy, laughter, and meaningful social connection to care homes in South Wales.Readmore

ALS survival may be cut short by living in disadvantaged communities

Social determinants of health negatively impact many diseases, including neurological conditionsReadmore

New study looks at nostalgia, comfort in food preparation for older adults

New Washington State University research highlights the importance of nostalgia, comfort, and texture variety in prepared meals for older adults, enhancing both enjoyment and nutrition.Readmore

Luteolin, an antioxidant in vegetables, may contribute to the prevention of hair graying

Luteolin, an antioxidant in vegetables, may help suppress graying hair, according to Nagoya University research.Readmore

New study uncovers how genes influence retinal aging and brain health

JAX researchers used mice with nine different genetic backgrounds to identify factors influencing eye aging, paving the way for eye-based diagnostics for neurodegenerative diseasesReadmore

Life span increases in mice when specific brain cells are activated

Brain cells communicate with fat tissue to produce cellular fuel, counteract effects of agingReadmore

Telomir Pharmaceuticals Confirms Lifespan Restoration and Normalization of Accelerated Aging in Preclinical Model of Progeria A Rare Genetic Disorder Causing Rapid Aging

The research, utilizing C.elegans models, demonstrated that Telomir was able to reverse shortened lifespans and restore normal aging processesReadmore

Meet the newly discovered brain cell that allows you to remember objects

Scientists at UBC’s faculty of medicine have discovered a new type of brain cell that plays a central role in our ability to remember and recognize objects.Readmore

A New Approach to Alzheimer’s? Study Finds Promising Therapeutic Target

New technique reveals how axon swellings could be treated in Alzheimer’s.Readmore

How the brain switches between persevering, trying something new, or giving up

A UCL-led study in mice has identified brain circuits responsible for decision-making, regulating perseverance, exploration, and disengagement. These findings provide insights into cognitive flexibility and adaptive behavior.Readmore

Next-gen Alzheimer’s drugs extend independent living by months

New analysis recasts benefits of treatment in relation to day-to-day impacts on patients’ livesReadmore

Is Plant Protein a Key to Healthy Aging for Women?

A recent major study of women showed that protein—particularly protein from plant food—is a key ingredient in healthy aging in women. More than 45,000 women participated in the study, and the results back up earlier research that emphasizes the benefiReadmore

Could a Drug Prevent Hearing Loss from Loud Music and Aging?

Researchers have found a gene that links deafness to cell death in the inner ear in humans – creating new opportunities for averting hearing loss.Readmore

Worm study shows hyperactivated neurons cause aging-related behavioral decline

Researchers at Nagoya University found that age-related cognitive decline is caused by neuronal hyperactivation, not reduced activity. Dietary changes may help regulate this and support healthy brain aging!Readmore

Schizophrenia and Aging May Share a Biological Basis

Synchronized changes in gene activity in brain cells may underlie cognitive impairment in both conditionsReadmore

Opening for a new type of drug for Alzheimer’s Disease

In Alzheimer’s disease, the tau protein changes in harmful ways. First, it clumps into small, soluble groups that are released from nerve cells and may spread damage to other cells.Readmore

Diagnosing Alzheimer’s disease using blood tests: p-tau biomarkers not as disease-specific as previously thought

Blood p-tau, once thought AD-specific, is also elevated in ALS, challenging its diagnostic precision but offering potential for ALS monitoring.Readmore

Do heatwaves make us age faster?

Researchers fear that climate change could contribute to increased rates of biological ageing, with implications for people’s long-term health. Readmore

Genetic research unlocks new ways to prevent and treat multiple long-term conditions

The largest study to date to analyse millions of both genetic and patient records on the long-term health conditions of later life has identified opportunities for new ways to prevent and treat multiple overlapping conditions.Readmore

Jefferson Investigates: Mood Changes after TBI, Chlamydia’s Cellular Tricks, Modulation of Pain Signals

Exploring depression and apathy in older TBI patients; how chlamydia survives in human cells; the molecular mechanisms behind intensified pain signals.Readmore

How air pollution and wildfire smoke may contribute to memory loss in Alzheimer’s disease

Scripps Research scientists discovered how a chemical modification of a key brain protein—potentially triggered by climate change-induced air pollution, pesticides, wildfires and processed meats—disrupts normal brain cell function.Readmore

Mouth bacteria may hold insight into future brain function

The bacteria in your mouth and on your tongue may be linked to changes in brain function as you age, new research suggested. Readmore

Researchers make breakthrough in bioprinting functional human heart tissue

Researchers at University of Galway have developed a way of bioprinting tissues that change shape as a result of cell-generated forces, in the same way that it happens in biological tissues during organ development.Readmore

FDA Approves LEQEMBI® (lecanemab-irmb) IV Maintenance Dosing for the Treatment of Early Alzheimer's Disease

The FDA has approved a new once-every-four-weeks maintenance dose of lecanemab-irmb for early Alzheimer’s disease. This schedule may make it easier for patients and caregivers to continue treatment.Readmore

A Fasting-Refeeding Paradigm Rejuvenates Old Stem Cells

The new study indicates that there is a way to turn back the clock to a younger time and rejuvenate these blood stem cells, restoring their ability to regenerate and fight off age-related diseases.Readmore

Important Grant to Study Health Equity in Alzheimer’s Treatment

NIH support will allow Brian Callaghan, M.D., to study the medical and cost effectiveness of new Alzheimer’s medications in underrepresented communities.Readmore

Olive oil may reduce risk of death from dementia

People who incorporate olive oil into their everyday diet may decrease their risk of dementia-related death, according to a new study by Harvard T.H. Chan School of Public Health.Readmore

Multi-year CIHR grant supports McMaster study at the intersection of aging and infectious disease

McMaster University researchers have received $750,000 from the Canadian Institutes of Health Research (CIHR) for a multi-year study into the connection between respiratory infections and brain aging.Readmore